| 세션명 | 기능성 고분자(III) |
|---|---|
| 발표장 | 포스터장 |
| 논문코드 | 3PS-193 |
| 발표일 | 2019-10-11 |
| 발표시간 | 16:00-17:30 (게시시간: 13:50-17:30) |
| 논문제목 | Hyaluronic acid / β-glucan Hybrid Nanogel for Transdermal Immunomodulation |
| 발표자 | 김현규 |
| 발표자 소속 | 서울대학교 |
| 저자 | 김현규, 이시영, 기창석† |
| 소속 | 서울대학교 |
| 논문초록 | Transdermal immunomodulation (TDIM) is a promising strategy to treat cancer or infectious diseases because it is not only non-invasive drug delivery but also efficient method avoiding a first pass effect. However, TDIM efficiency is generally low for difficulty of skin penetration as well as immune cell targeting. In this study, hyaluronic acid and β-glucan were hybridized via photo-crosslinking and fabricated into nanogel of which size was in the range of 150-200 nm. The hybrid nanogels efficiently penetrated porcine skin and were deposited in dermis. In dendritic cell uptake assay, the cellular uptake of the hybrid nanogel increased with an increase of β-glucan and incorporated ovalbumin (i.e., model drug) was successfully delivered to dendritic cells. |
THE POLYMER SOCIETY OF KOREA